Treatment method with ACE inhibitors or angiotensin receptor antagonists allows to manage blood pressure and decrease renal ailment development. Bilateral nephrectomy when substantial renal microvascular thrombosis, refractory hypertension, and indications of hypertensive encephalopathy are usually not responsive to conventional therapies, such as
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Around eighty% of TTP is triggered by deficient activity of ADAMTS13. ADAMTS13 deficiency might be constitutive, because of biallelic ADAMTS13 pathogenic variants; or obtained, on account of an inhibitory antibody. Analysis of ADAMTS13 activity is done applying tests determined by the capability from the protease to cleave common VWF multimers in v